全文获取类型
收费全文 | 9933篇 |
免费 | 790篇 |
国内免费 | 282篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 443篇 |
妇产科学 | 65篇 |
基础医学 | 2070篇 |
口腔科学 | 30篇 |
临床医学 | 973篇 |
内科学 | 2297篇 |
皮肤病学 | 746篇 |
神经病学 | 188篇 |
特种医学 | 101篇 |
外科学 | 939篇 |
综合类 | 1735篇 |
预防医学 | 210篇 |
眼科学 | 78篇 |
药学 | 614篇 |
3篇 | |
中国医学 | 469篇 |
肿瘤学 | 32篇 |
出版年
2024年 | 5篇 |
2023年 | 165篇 |
2022年 | 204篇 |
2021年 | 298篇 |
2020年 | 316篇 |
2019年 | 357篇 |
2018年 | 322篇 |
2017年 | 304篇 |
2016年 | 327篇 |
2015年 | 324篇 |
2014年 | 554篇 |
2013年 | 849篇 |
2012年 | 484篇 |
2011年 | 543篇 |
2010年 | 432篇 |
2009年 | 451篇 |
2008年 | 466篇 |
2007年 | 513篇 |
2006年 | 468篇 |
2005年 | 395篇 |
2004年 | 421篇 |
2003年 | 329篇 |
2002年 | 328篇 |
2001年 | 267篇 |
2000年 | 230篇 |
1999年 | 203篇 |
1998年 | 160篇 |
1997年 | 144篇 |
1996年 | 106篇 |
1995年 | 122篇 |
1994年 | 122篇 |
1993年 | 120篇 |
1992年 | 100篇 |
1991年 | 84篇 |
1990年 | 91篇 |
1989年 | 53篇 |
1988年 | 58篇 |
1987年 | 43篇 |
1986年 | 40篇 |
1985年 | 41篇 |
1984年 | 41篇 |
1983年 | 22篇 |
1982年 | 31篇 |
1981年 | 20篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1978年 | 13篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 21 毫秒
71.
Aliko A Ciancaglini R Alushi A Tafaj A Ruci D 《International journal of oral and maxillofacial surgery》2011,40(7):704-709
The aim of the present study was to estimate the prevalence of temporomandibular joint (TMJ) symptoms and clinical findings in Albanian patients with rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. The authors examined 124 consecutive hospitalized patients (88 with rheumatoid arthritis, 22 with systemic lupus erythematosus and 14 with systemic sclerosis) and 124 age- and gender-matched healthy controls using a questionnaire and an oro-facial clinical examination for assessing the presence of TMJ sounds, pain in the TMJ area, tenderness of masticatory muscles and limited mouth opening. Significantly more patients (67%) reported TMJ symptoms than controls (19%). A significantly higher proportion of patients (65%) exhibited clinical signs of temporomandibular dysfunction compared with controls (26%). The most frequent findings in rheumatoid arthritis were temporomandibular sounds and pain. Pain was found in a significantly higher proportion in patients with systemic lupus erythematosus compared with controls. Difficulty and limitation in mouth opening were observed in the majority of systemic sclerosis patients, and in only a minority of rheumatoid arthritis patients. This study supports the notion that TMJ examination should be encouraged in the rheumatology setting and clinicians should be able to provide pain management and patient support. 相似文献
72.
《Saudi Dental Journal》2022,34(8):708-714
ObjectiveThis study aimed to investigate the influence of periodontal status, clinical data, and serum markers on salivary leptin levels in patients with systemic lupus erythematosus (SLE).MethodsA case–control study was conducted with 38 patients with SLE and 29 healthy controls. Periodontal data included periodontal probing depth (PPD), clinical attachment level (CAL), and gingival bleeding on probing (BOP). Stimulated saliva samples were collected to analyze salivary leptin levels. Clinical and serum data were collected from the SLE group. Statistical analysis included the t-test, Mann–Whitney test, Spearman correlation coefficient, and a structural equation model.ResultsThe SLE group had a lower salivary leptin level than the control group (P = 0.002). The model revealed that SLE had an inverse and independent effect on salivary leptin (standardized estimate = ? 0.289, P = 0.023). Moreover, salivary leptin level negatively correlated with the serum levels of triglyceride, creatinine, and leukocytes, positively correlated with the serum total cholesterol, but was not significantly correlated with the periodontal status.ConclusionThese findings suggest that patients with SLE have a lower salivary leptin level. In addition, the level of salivary leptin does not appear to be related to periodontal status in patients with SLE. 相似文献
73.
74.
75.
76.
Gabriella Moroni Mariele Gatto Francesca Raffiotta Valentina Binda Eleni Frangou Liz Lightstone Dimitrios T. Boumpas 《Autoimmunity reviews》2018,17(1):11-18
Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far. 相似文献
77.
Sara Tenti Marta Fabbroni Virginia Mancini Filomena Russo Mauro Galeazzi Antonella Fioravanti 《Autoimmunity reviews》2018,17(8):791-795
Discoid lupus erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, alopecia and dyspigmentation, if not properly treated. Actually, no drugs are specifically approved for the treatment of CLE, although the first-line therapy usually consists of photoprotection associated to topical or oral steroids, topical calcineurin inhibitors and hydroxychloroquine (HCQ). In cases of DLE refractory to these medications, many other agents have been employed, such as dapsone, methotrexate, azathioprine, cyclophosphamide, biologic drugs and Intravenous Immunoglobulin (IVIG).We described the case of a DLE patient resistant to combination therapy with steroid and HCQ who was successfully treated with cyclical IVIG therapy. The treatment with IVIG resulted rapidly effective with persistent efficacy and low rates of relapses, although more cycles of IVIG are needed to achieve a stable clinical remission.We also discussed the beneficial and promising effects of IVIG in patients with Cutaneous Lupus reporting the previously published data. 相似文献
78.
Franziska Sotzny Julià Blanco Enrica Capelli Jesús Castro-Marrero Sophie Steiner Modra Murovska Carmen Scheibenbogen 《Autoimmunity reviews》2018,17(6):601-609
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent and severe chronic disease drastically impairing life quality. The underlying pathomechanism is incompletely understood yet but there is convincing evidence that in at least a subset of patients ME/CFS has an autoimmune etiology. In this review, we will discuss current autoimmune aspects for ME/CFS. Immune dysregulation in ME/CFS has been frequently described including changes in cytokine profiles and immunoglobulin levels, T- and B-cell phenotype and a decrease of natural killer cell cytotoxicity. Moreover, autoantibodies against various antigens including neurotransmitter receptors have been recently identified in ME/CFS individuals by several groups. Consistently, clinical trials from Norway have shown that B-cell depletion with rituximab results in clinical benefits in about half of ME/CFS patients. Furthermore, recent studies have provided evidence for severe metabolic disturbances presumably mediated by serum autoantibodies in ME/CFS. Therefore, further efforts are required to delineate the role of autoantibodies in the onset and pathomechanisms of ME/CFS in order to better understand and properly treat this disease. 相似文献
79.
Wen-Yi Tseng Yeong-Jian Jan Wu Tai-Yun Yang Nien-Yi Chiang Wen-Pin Tsai Siamon Gordon Gin-Wen Chang Chang-Fu Kuo Shue-Fen Luo Hsi-Hsien Lin 《Journal of microbiology, immunology, and infection》2018,51(4):485-491
Background
GPR56/ADGRG1 is a member of the adhesion-class G protein-coupled receptor (aGPCR) family important in brain development, oncogenesis and tumor metastasis. Like other aGPCRs, GPR56 is cleaved at the GPCR proteolysis site (GPS) motif into an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Existence of soluble GPR56 (sGPR56) has been shown in vitro, however the underlying mechanism and its pathophysiologic role remains undetermined.Objective
To assess the presence of sGPR56 in human serum using ELISA assay and compare the serum sGPR56 levels among patients of various chronic inflammatory diseases and healthy subjects.Patients and methods
In this study, serum samples from patients with systemic lupus erythematosus (SLE) (n = 57), rheumatoid arthritis (RA) (n = 95), Sjögren's syndrome (SS) (n = 29), ankylosing spondylitis (AS) (n = 51), and normal controls (n = 81) were analyzed using sGPR56-specific ELISA.Result
We show that serum sGPR56 levels are increased in patients of RA, but not in those with SLE, SS and AS. Intriguingly, serum sGPR56 levels in RA patients correlated with positive rheumatoid factor, a marker of bone erosion and poor outcome. In addition, an elevated sGPR56 level is also noted in RA patients with higher tumor necrosis factor level.Conclusion
we conclude that sGPR56 is present in vivo and sGPR56 level is elevated in certain chronic inflammatory diseases such as RA. Hence, sGPR56 might be considered a potential biomarker for RA disease progression. 相似文献80.